Synthesis and biological evaluation of selective phosphonate-bearing 1,2,3-triazole-linked sialyltransferase inhibitors
Christopher Dobie, Andrew P. Montgomery, Rémi Szabo, Haibo Yu, Danielle Skropeta
Abstract
ranging from 3-55 μM. This work highlights phosphonate bearing triazole-linked compounds as a promising class of synthetically accessible ST inhibitors that warrant further investigation.
Topics & Concepts
SialyltransferasePhosphonateChemistryTriazoleEnzymeBiochemistryPotencyPharmacologyCombinatorial chemistryIn vitroCancer researchBiologyOrganic chemistryGlycosylation and Glycoproteins ResearchPeptidase Inhibition and AnalysisMonoclonal and Polyclonal Antibodies Research