Synthetic Control of Mitochondrial Dynamics: Developing Three-Coordinate Au(I) Probes for Perturbation of Mitochondria Structure and Function
R. Tyler Mertens, William C. Jennings, Samuel Ofori, Jong Hyun Kim, Sean Parkin, Gunnar F. Kwakye, Samuel G. Awuah
Abstract
in mice demonstrates its preclinical utility. This work provides a basis for rational design of gold-based agents to control mitochondrial structure and dynamics.
Topics & Concepts
Mitochondrionmitochondrial fusionCell biologyRational designNeurodegenerationBiophysicsInner mitochondrial membraneMitochondrial permeability transition poreChemistryBiologyComputational biologyBiochemistryDiseaseApoptosisMedicineProgrammed cell deathPathologyMitochondrial DNAGeneticsGeneMetal complexes synthesis and propertiesMitochondrial Function and PathologyNanocluster Synthesis and Applications