3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury
Haojie Zhang, Wenfei Ni, Gaoxiang Yu, Yibo Geng, Junsheng Lou, Jianjun Qi, Yituo Chen, Feida Li, Hantao Ye, Haiwei Ma, Hui Xu, Luying Zhao, Yuepiao Cai, Xiangyang Wang, Huazi Xu, Jian Xiao, Kailiang Zhou
Abstract
3,4-DC promotes functional recovery by upregulating TFEB-mediated autophagy and inhibiting pyroptosis and necroptosis after SCI, which may have potential clinical application value.
Topics & Concepts
PyroptosisNecroptosisAutophagyCell biologyChemistrySpinal cord injuryProgrammed cell deathPharmacologyBiologyNeuroscienceApoptosisBiochemistrySpinal cordAutophagy in Disease and TherapySpinal Cord Injury ResearchFamily and Disability Support Research