Pax5 regulates B cell immunity by promoting PI3K signaling via PTEN down-regulation
Lesly Calderón, Karina Schindler, Stephen Malin, Alexandra Schebesta, Qiong Sun, Tanja A. Schwickert, Chiara Alberti, Maria Fischer, Markus Jaritz, Hiromi Tagoh, Anja Ebert, Martina Minnich, Adrian Liston, Luisa Cochella, Meinrad Busslinger
Abstract
double-mutant mice rescued FO B cell numbers and the development of MZ B cells but did not restore GC B cell formation. Hence, the posttranscriptional down-regulation of PTEN expression is an important function of Pax5 that facilitates the differentiation and survival of mature B cells, thereby promoting humoral immunity.
Topics & Concepts
PTENPAX5ImmunitySignal transductionPI3K/AKT/mTOR pathwayB cellCell biologyBiologyCancer researchImmunologyImmune systemAntibodyPI3K/AKT/mTOR signaling in cancerViral-associated cancers and disordersImmune Cell Function and Interaction