Antidepressants for pain management in adults with chronic pain: a network meta-analysis
Hollie Birkinshaw, Claire Friedrich, Peter Cole, Christopher Eccleston, Marc Serfaty, Gavin Stewart, Simon White, Andrew Moore, Tamar Pincus
Abstract
Chronic pain is common in adults, and o en has a detrimental impact upon physical ability, well-being, and quality of life. Previous reviews have shown that certain antidepressants may be e ective in reducing pain with some benefit in improving patients' global impression of change for certain chronic pain conditions. However, there has not been a network meta-analysis (NMA) examining all antidepressants across all chronic pain conditions.
Topics & Concepts
MoodAdverse effectMedicineChronic painDepression (economics)Quality of life (healthcare)Meta-analysisIntervention (counseling)PsychiatryPhysical therapyInternal medicineNursingEconomicsMacroeconomicsMusculoskeletal pain and rehabilitationPain Mechanisms and TreatmentsPain Management and Placebo Effect