Unraveling the Microbiome of Necrotizing Enterocolitis: Insights in Novel Microbial and Metabolomic Biomarkers
Chiara Tarracchini, Christian Milani, Giulia Longhi, Federico Fontana, Leonardo Mancabelli, Roberta Pintus, Gabriele Andrea Lugli, Giulia Alessandri, Rosaria Anzalone, Alice Viappiani, Francesca Turroni, Michele Mussap, Angelica Dessì, Flaminia Cesare Marincola, Antonio Noto, Anna De Magistris, Marine Vincent, Sergio Bernasconi, Jean‐Charles Picaud, Vassilios Fanos, Marco Ventura
Abstract
Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease occurring predominantly in premature infants whose etiology is still not fully understood. In this study, the analysis of infant fecal samples through shotgun metagenomics approaches revealed a marked reduction of the intestinal (bio)diversity and an overgrowth of (opportunistic) pathogens associated with the NEC development.