Differential H4K16ac levels ensure a balance between quiescence and activation in hematopoietic stem cells
Cecília Pessoa Rodrigues, Asifa Akhtar
Abstract
levels correlate with poor survival and increased proliferation capacity in leukemia. Collectively, our study indicates H4K16ac as an important determinant for HSC heterogeneity, which is linked to the onset of monocytic disorders.
Topics & Concepts
HaematopoiesisStem cellCell biologyBiologyBalance (ability)Hematopoietic stem cellDifferential (mechanical device)Computational biologyChemistryNeurosciencePhysicsThermodynamicsImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses