Visible <scp>Light‐Mediated</scp> Construction of Sulfonated Dibenzazepines
Chuan‐Hua Qu, Gui‐Ting Song, Jian‐Hua Ou, Dianyong Tang, Zhigang Xu, Zhong‐Zhu Chen
Abstract
Main observation and conclusion A new method to access sulfonated dibenz[ b , e ]azepines via visible‐light photoredox catalysis is described. Employing inexpensive and commercially available sulfonyl chlorides to form the sulfonyl radicals enables the alkyne addition reaction followed by a 7‐membered radical cyclization step to furnish sulfonated dibenzazepines. In addition, an Ugi‐type multicomponent reaction (MCR) for the synthesis of o ‐aminophenylacetylene derivatives can also be used as a rapid substrate synthesis method for the cascade radical cyclization protocol to obtain a series of highly functionalized sulfonylated dibenzazepines, which undoubtedly greatly simplifies the synthetic steps of the dibenzazepine compounds that are important core structures in pharmaceuticals.