Enhanced availability of serotonin limits muscle activation during high-intensity, but not low-intensity, fatiguing contractions
Tyler T. Henderson, Janet L. Taylor, Jacob R. Thorstensen, Murray G. Tucker, Justin J. Kavanagh
Abstract
As serotonin release onto motoneurons may be scaled to the strength of muscle contraction, it may have different effects when neuromuscular fatigue is induced by contractions of different intensities. Enhanced levels of serotonin compromised voluntary activation of muscle when fatigue was induced by strong contractions but not weak contractions. This provides evidence that the serotonergic system has the greatest influence on fatigue that is generated with high neural drive to the target muscle.
Topics & Concepts
Isometric exerciseTranscranial magnetic stimulationMuscle contractionMotor cortexSerotoninStimulationMuscle fatigueNeuroscienceContraction (grammar)Internal medicinePsychologyElectromyographyPhysical medicine and rehabilitationEndocrinologyMedicineReceptorMuscle activation and electromyography studiesTranscranial Magnetic Stimulation StudiesNeuroscience and Neural Engineering