Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells
Ruiran Wei, Yueqin Zhao, Juan Wang, Yang Xu, Shun‐Lin Li, Yinyuan Wang, Xing‐Zhi Yang, Jimin Fei, Xiao‐Jiang Hao, Yuhan Zhao, Liming Gui, Xiao Ding
Abstract
Rationale: Colorectal cancer (CRC) is a common malignant tumor of the digestive system. However, the efficacy of surgery and chemotherapy is limited. Ferroptosis is an iron-and reactive oxygen species (ROS)-dependent form of regulated cell death (RCD) and plays a vital role in tumor suppression. Ferroptosis inducing agents have been studied extensively as a novel promising way to fight against therapy resistant cancers. The aim of this study is to investigate the mechanism of action of tagitinin C (TC), a natural product, as a novel ferroptosis inducer in tumor suppression.
Topics & Concepts
Oxidative stressLipid peroxidationCancer researchReactive oxygen speciesCancer cellApoptosisClonogenic assayProgrammed cell deathViability assayChemistryCancerBiologyMolecular biologyCell biologyBiochemistryGeneticsFerroptosis and cancer prognosisCancer, Lipids, and MetabolismDrug Transport and Resistance Mechanisms