Manganese-induced α-synuclein overexpression promotes the accumulation of dysfunctional synaptic vesicles and hippocampal synaptotoxicity by suppressing Rab26-dependent autophagy in presynaptic neurons
Zhuo Ma, Kuan Liu, Ruifeng Zhang, Zixin Xie, Wei Liu, Yu Deng, Xin Li, Bin Xu
Topics & Concepts
AutophagySmall hairpin RNAHippocampal formationColocalizationSynapseHippocampusSynaptic vesicleCell biologyChemistrySynapsin INeuronIn vivoSynaptic plasticityNeuroscienceTransfectionGene knockdownBiologyEndocrinologyVesicleBiochemistryReceptorApoptosisMembraneBiotechnologyGeneNeuroscience and Neuropharmacology ResearchAutophagy in Disease and TherapyAlzheimer's disease research and treatments