Optogenetic and chemogenetic approaches reveal differences in neuronal circuits that mediate initiation and maintenance of social interaction
Karolina Rojek-Sito, Ksenia Meyza, Karolina Ziegart-Sadowska, Kinga Nazaruk, Alicja Puścian, Adam Hamed, Michał Kiełbiński, Wojciech Solecki, Ewelina Knapska
Abstract
SocialAU : PleasenotethattheSummaryhasbeenremovedfromthetext:PLOSBiologydoesnotdoauthorsumm species, including humans, are motivated not only by physiological needs such as food, water, or reproduction but also by the need to interact with other individuals and form relationships. The neural circuits promoting social interactions remain poorly understood. Previous studies implicated the neural circuits within the mesocorticolimbic reward system, including the ventral tegmental area (VTA), nucleus accumbens (NAc), central amygdala (CeA), orbitofrontal cortex (OFC), and anterior cingulate cortex (ACC) in social interaction