Discovery of small-molecule enzyme activators by activity-based protein profiling
Bernard P. Kok, Srijana Ghimire, Woojoo E. Kim, Shreyosree Chatterjee, Tyler Johns, Seiya Kitamura, Jérôme Eberhardt, Daisuke Ogasawara, Janice H. Xu, Ara Sukiasyan, Sean Kim, Cristina Godio, Julia M. Bittencourt, Michael D. Cameron, Andrea Galmozzi, Stefano Forli, Dennis W. Wolan, Benjamin F. Cravatt, Dale L. Boger, Enrique Sáez
Topics & Concepts
Small moleculeChemistryProfiling (computer programming)EnzymeComputational biologyDrug discoveryBiochemistryCell biologyBiologyComputer scienceOperating systemProtein Structure and DynamicsUbiquitin and proteasome pathwaysGlycosylation and Glycoproteins Research