Epigenetically silenced PD-L1 confers drug resistance to anti-PD1 therapy in gastric cardia adenocarcinoma
Tianyu Zhu, Zhihao Hu, Zhuoyin Wang, Hengxuan Ding, Ruixin Li, Junfeng Sun, Guojun Wang
Topics & Concepts
MethylationDNA methylationPD-L1Cancer researchAdenocarcinomaHypomethylating agentCancerBisulfite sequencingBisulfiteCombination therapyMolecular biologyMedicineBiologyGeneInternal medicineImmunotherapyGene expressionBiochemistryCancer Immunotherapy and BiomarkersEpigenetics and DNA MethylationImmune cells in cancer