Inhibiting NLRP3 inflammasome with MCC950 ameliorates perioperative neurocognitive disorders, suppressing neuroinflammation in the hippocampus in aged mice
Qun Fu, Jing Li, Lili Qiu, Jiaping Ruan, Mingjie Mao, Shu‐Ming Li, Qing-Hong Mao
Topics & Concepts
NeuroinflammationInflammasomeGlial fibrillary acidic proteinPostoperative cognitive dysfunctionMedicinePostsynaptic densityNeurotrophic factorsHippocampusInternal medicineEndocrinologyAnesthesiaReceptorPharmacologyGlutamate receptorInflammationPsychiatryCognitionImmunohistochemistryAnesthesia and Neurotoxicity ResearchIntensive Care Unit Cognitive DisordersInflammasome and immune disorders