Arthrocentesis versus conservative treatments for temporomandibular joint disorders: A systematic review with meta-analyses and trial sequential analyses
Yang Tang, N.B. van Bakelen, Barzi Gareb, Fred K. L. Spijkervet
Abstract
This systematic review aimed to evaluate the efficacy of arthrocentesis compared to conservative treatments for symptomatic temporomandibular joint disorders. A systematic search for randomized, prospective and retrospective controlled trials was undertaken in five electronic databases. Various patient outcomes and economic evaluations were analysed for short-term (<6 months), intermediate-term (6 months to 5 years) and long-term (≥5 years) follow-up periods. Primary meta-analyses were performed for randomized controlled trials using random-effects models. Arthrocentesis was superior to conservative treatments regarding pain reduction at short-term (MD 14.5 (95% CI 9.7; 19.4), k= 9 RCTs, n= 545 patients, I 2 = 48%, high quality of evidence) and intermediate-term follow-up (MD 14.2 (95% CI 7.3; 21.1), k= 9 RCTs, n= 547 patients, I 2 = 81%, moderate quality of evidence). Furthermore, arthrocentesis was superior to conservative treatment regarding maximum mouth opening improvement at short-term (MD 2.4 mm (95% CI 0.8; 4.1), k= 8 RCTs, n= 472 patients, I 2 = 80%, moderate quality of evidence) and intermediate-term follow-up (MD 2.2 mm (95% CI 0.5; 3.9), k= 8 RCTs, n= 468 patients, I 2 = 75%, moderate quality of evidence). Trial sequential analysis supported the conclusions of all primary meta-analyses. Results were clinically relevant for pain improvement, but not for maximum mouth opening improvement. Results at long-term follow-up and for other study outcomes were either lacking or too heterogenous for meta-analysis, highlighting the need for more standardized, high-quality research.