Water-soluble amphiphilic ruthenium(<scp>ii</scp>) polypyridyl complexes as potential light-activated therapeutic agents
Sandra Estalayo-Adrián, Salvador Blasco, Sandra A. Bright, Gavin McManus, Guillermo Orellana, D. Clive Williams, John M. Kelly, Thorfinnur Gunnlaugsson
Abstract
Two water-soluble amphiphilic Ru(ii) polypyridyl complexes containing N-1,10-phenanthrolin-5-yldocosanamide and 1,10-phenanthroline (phen) or 1,4,5,8-tetraazaphenanthrene (TAP) as ligands were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and displayed phototoxicity against HeLa cervical cancer cells.
Topics & Concepts
RutheniumAmphiphileChemistryWater solubleCombinatorial chemistryOrganic chemistryCatalysisCopolymerPolymerMetal complexes synthesis and propertiesClick Chemistry and ApplicationsAdvanced biosensing and bioanalysis techniques