Vitamin D3 and its hydroxyderivatives as promising drugs against COVID-19: a computational study
Yuwei Song, Yuwei Song, Shariq Qayyum, Rory A. Greer, Radomir M. Slominski, Chander Raman, Andrzej Słomiński, Yuhua Song, Yuhua Song
Abstract
D3 with TMPRSS2 also caused the conformational and dynamical motion changes of TMPRSS2, which could affect TMPRSS2 to prime SARS-CoV-2 spike proteins. Our results propose that vitamin D3 and its biologically active hydroxyderivatives are promising drugs or adjuvants in the treatment of COVID-19. Communicated by Ramaswamy H. Sarma.
Topics & Concepts
TMPRSS2Molecular dynamicsChemistryDocking (animal)Binding sitePlasma protein bindingBiophysicsCoronavirus disease 2019 (COVID-19)BiologyBiochemistryMedicineInternal medicineComputational chemistryInfectious disease (medical specialty)DiseaseNursingVitamin D Research StudiesVitamin C and Antioxidants ResearchCOVID-19 Clinical Research Studies