Site-selective editing of peptides <i>via</i> backbone modification
Junjie Shi, Tong Sun, Mingyu Yang
Abstract
The site-selective modifications of peptide backbones have a significant impact on peptide conformation, folding ability, and physicochemical and biological properties. This review discusses the site-selective modifications of peptide backbones and classifies them into four categories.
Topics & Concepts
ChemistryPeptideFolding (DSP implementation)Combinatorial chemistryPosttranslational modificationStereochemistryComputational biologyBiochemistryEnzymeEngineeringBiologyElectrical engineeringChemical Synthesis and AnalysisClick Chemistry and ApplicationsBiochemical and Structural Characterization