Synthesis and anti-tumor activity evaluation of salinomycin C20-<i>O</i>-alkyl/benzyl oxime derivatives
Bo Li, Jun Wu, Lei Tang, Xu Lian, Zhongwen Li, Wenfang Duan, Tong Qin, Xintong Zhao, Yuhua Hu, Chi Zhang, Tianlei Li, Jie Hao, Wenxuan Zhang, Jihong Zhang, Song Wu
Abstract
Seventeen C20- O -alkyl/benzyl oxime derivatives were synthesized by a concise and effective method, which showed 15~240 folds better antiproliferative activity, more potent ion binding and transport ability and better selectivity indexes (SI) than salinomycin.
Topics & Concepts
ChemistrySalinomycinOximeAlkylPotencySelectivityMedicinal chemistryStereochemistryIn vitroBiochemistryOrganic chemistryCatalysisAntibioticsBioactive Compounds and Antitumor AgentsAntimicrobial Peptides and ActivitiesChemical Synthesis and Analysis