Cycling Stem Cells Are Radioresistant and Regenerate the Intestine
Xiaole Sheng, Ziguang Lin, Cong Lv, Chunlei Shao, Xueyun Bi, Min Deng, Jiuzhi Xu, Christian F. Guerrero‐Juarez, Mengzhen Li, Xi Wu, Ran Zhao, Xu Yang, Guilin Li, Xiaowei Liu, Qingyu Wang, Qing Nie, Wei Cui, Shan Gao, Hongquan Zhang, Zhihua Liu, Yingzi Cong, Maksim V. Plikus, Christopher J. Lengner, Bogi Andersen, Fazheng Ren, Zhengquan Yu
Abstract
Quiescent reserve stem cells in the intestine are thought to activate following irradiation to restore the depleted Lgr5 high CBCs. Now, Sheng et al. demonstrate that cycling Msi1 + cells represent DNA damage-resistant ISCs that support efficient repopulation of the intestinal epithelium at the early stage of postradiation repair, ahead of Lgr5 high CBCs.
Topics & Concepts
LGR5Stem cellBiologyCell biologyIntestinal epitheliumCryptRadioresistanceEpitheliumPaneth cellIntestinal mucosaRegeneration (biology)DNA damageAdult stem cellCellular differentiationImmunologySmall intestineCancer stem cellDNACell cultureGeneticsGeneMedicineBiochemistryInternal medicineEndocrinologyCancer Cells and MetastasisEpigenetics and DNA MethylationDigestive system and related health