Persistent STAT5 activation reprograms the epigenetic landscape in CD4 <sup>+</sup> T cells to drive polyfunctionality and antitumor immunity
Zhi-Chun Ding, Huidong Shi, Nada S. Aboelella, Kateryna Fesenkova, Eun-Jeong Park, Zhuoqi Liu, Lirong Pei, Jiaqi Li, Richard McIndoe, Hongyan Xu, Gary A. Piazza, Bruce R. Blazar, David H. Munn, Gang Zhou
Abstract
Persistent STAT5 activation endows antitumor CD4 + T cells with desirable functional features that optimize adoptive T cell therapy.
Topics & Concepts
EpigeneticsImmunityBiologySTAT5Cell biologyChemistryCancer researchImmunologyImmune systemGeneGeneticsSignal transductionCAR-T cell therapy researchImmune Cell Function and InteractionImmunotherapy and Immune Responses