Compensatory combination of mTOR and TrxR inhibitors to cause oxidative stress and regression of tumors
Yiqun Xia, Jundixia Chen, Yun Yu, Fengjiao Wu, Xin Shen, Chenyu Qiu, Tingting Zhang, Hong Lin, Peisen Zheng, Rongrong Shao, Chenxin Xu, Fang Wu, Wei Chen, Congying Xie, Ri Cui, Peng Zou
Abstract
Our findings identify a promising therapeutic combination for cancer and has important implications for developing mTOR inhibitor-based combination treatments.
Topics & Concepts
Oxidative stressDiscovery and development of mTOR inhibitorsPI3K/AKT/mTOR pathwayCancer researchMedicineChemistryPharmacologyOncologyInternal medicineApoptosisBiochemistryRedox biology and oxidative stressGenomics, phytochemicals, and oxidative stressFree Radicals and Antioxidants