Intra-Arterial Chemotherapy for Retinoblastoma in Infants ≤10 kg: 74 Treated Eyes with 222 IAC Sessions
Ahmad Sweid, Batoul Hammoud, Joshua Weinberg, Pavlos Texakalidis, Vivian Xu, Kavya Shivashankar, Michael P. Baldassari, Somnath Das, Sunidhi Ramesh, Stavropoula Tjoumakaris, Carol L. Shields, David Ancona‐Lezama, Li‐AnneL Lim, Lauren A. Dalvin, Pascal Jabbour
Abstract
BACKGROUND AND PURPOSE: Intra-arterial chemotherapy for retinoblastoma has dramatically altered the natural history of the disease. The remarkable outcomes associated with a high safety profile have pushed the envelope to offer treatment for patients weighing ≤10 kg. The purpose was to determine the efficacy and safety of IAC infusions performed in infants weighing ≤10 kg with intraocular retinoblastoma. MATERIALS AND METHODS: A retrospective chart review was performed for patients diagnosed with retinoblastoma and managed with intra-arterial chemotherapy. RESULTS: = .01). On multivariate analysis, weight ≤10 kg was not an independent predictor of complications or procedure failure. CONCLUSIONS: Intra-arterial chemotherapy in patients weighing ≤10 kg is a safe and effective treatment.