Four Novel Leaderless Bacteriocins, Bacin A1, A2, A3, and A4 Exhibit Potent Antimicrobial and Antibiofilm Activities against Methicillin-Resistant Staphylococcus aureus
Shu Liu, Shulin Deng, Hualin Liu, Liang Tang, Mengqi Wang, Bingyue Xin, Feng Li
Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is a major human pathogen that is difficult to treat because of its resistance to several widely used antibiotics. The present study aimed to identify novel anti-MRSA bacteriocins in a prominent producer of bacteriocins, Bacillus cereus group. Four novel leaderless bacteriocins, bacin A1, A2, A3, and A4, which show potent bactericidal effect against S. aureus and MRSA, were identified in Bacillus sp. TL12. Moreover, bacins inhibited biofilm formation and killed cells in the established biofilms of S. aureus and MRSA. These findings suggest that bacins are promising alternatives to treat MRSA infections.
Topics & Concepts
Staphylococcus aureusBacteriocinAntimicrobialMicrobiologyMethicillin-resistant Staphylococcus aureusStaphylococcal infectionsBiologyBacteriaGeneticsProbiotics and Fermented FoodsBacterial biofilms and quorum sensingBiochemical and Structural Characterization