Association of Localizing <sup>18</sup> F-FDG-PET Hypometabolism and Outcome Following Epilepsy Surgery
Merran R. Courtney, Ana Antonic‐Baker, Zhibin Chen, Benjamin Sinclair, John‐Paul Nicolo, Andrew Neal, Cassandra Marotta, Jacob Bunyamin, Meng Law, Patrick Kwan, Terence J. O’Brien, Lucy Vivash
Abstract
BACKGROUND AND OBJECTIVES: F-FDG-PET hypometabolism is associated with favorable outcome after epilepsy surgery. METHODS: F-FDG-PET hypometabolism, defined as concordant with the epilepsy surgery resection zone. Meta-regression was used to characterize sources of heterogeneity. RESULTS: F-FDG-PET hypometabolism was associated with worse outcomes compared with focal hypometabolism (OR 0.34, 95% CI 0.22-0.54). DISCUSSION: F-FDG-PET into routine noninvasive investigations for patients being evaluated for epilepsy surgery to improve epileptogenic zone localization and to aid patient selection for surgery.