Inhibition of Microtubule Dynamics in Cancer Cells by Indole-Modified Latonduine Derivatives and Their Metal Complexes
Christopher Wittmann, Anastasiia S. Sivchenko, Felix Bacher, Kelvin K. H. Tong, Navjot Guru, Thomas C. Wilson, Junior Gonzales, Hartmut Rauch, Susanne Kossatz, Thomas Reiner, Maria V. Babak, Vladimir B. Arion
Abstract
tubulin polymerization assays revealed the prepared compounds to have excellent microtubule-destabilizing activities, even more potent than the well-known microtubule-destabilizing agent colchicine.
Topics & Concepts
ChemistryMicrotubuleColchicineTubulinIn vitroCytotoxicityIndole testIn vivoMetalStereochemistryFluorescenceProton NMRMicrotubule polymerizationNuclear magnetic resonance spectroscopyMass spectrometryCarbon-13 NMRCombinatorial chemistryOrganic chemistryBiochemistryChromatographyMedicineQuantum mechanicsBiologyBiotechnologyCell biologyInternal medicinePhysicsCancer Treatment and PharmacologyCancer therapeutics and mechanismsBioactive Compounds and Antitumor Agents