Discovery of new 3-methylquinoxalines as potential anti-cancer agents and apoptosis inducers targeting VEGFR-2: design, synthesis, and <i>in silico</i> studies
Mohammed M. Alanazi, Alaa Elwan, Nawaf A. Alsaif, Ahmad J. Obaidullah, Hamad M. Alkahtani, Abdulrahman A. Al-Mehizia, Sultan M. Alsubaie, Mohammed S. Taghour, Ibrahim H. Eissa
Abstract
studies, the synthesised compounds showed binding mode similar to that of the reference compound (sorafenib).
Topics & Concepts
SorafenibApoptosisChemistryIn silicoIC50Cancer cellLigand efficiencyCell cycleDocking (animal)Cytotoxic T cellLead compoundCell growthPharmacologyCytotoxicityIn vitroCancerCancer researchBiochemistryBiologyReceptorLigand (biochemistry)MedicineGeneGeneticsNursingHepatocellular carcinomaSynthesis and Biological EvaluationQuinazolinone synthesis and applicationsSynthesis and biological activity