MR1- and HLA-E-Dependent Antigen Presentation of Mycobacterium tuberculosis
Se-Jin Kim, Elham Karamooz
Abstract
MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from Mycobacterium tuberculosis to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells. MR1 presents small microbial metabolites, and HLA-E presents peptides and glycopeptides. In this review, we will discuss the current understanding of MR1 and HLA-E antigen presentation in the context of Mycobacterium tuberculosis infection.
Topics & Concepts
Mycobacterium tuberculosisAntigenHuman leukocyte antigenTuberculosisAntigen presentationContext (archaeology)ImmunologyBiologyCD8MicrobiologyT cellImmune systemMedicinePathologyPaleontologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisInfectious Diseases and Tuberculosis