Effect of hydroxyl on antioxidant properties of 2,3-dihydro-3,5-dihydroxy-6-methyl-4<i>H</i>-pyran-4-one to scavenge free radicals
Zhifei Chen, Qiang Liu, Zhiwei Zhao, Bing Bai, Zhitao Sun, Lili Cai, Yufeng Fu, Yuping Ma, Qingfu Wang, Gaolei Xi
Abstract
), 2,2'-diphenyl-1-picrylhydrazyl radical (DPPH), and galvinoxyl radical, respectively. It was found that the introduction of protecting groups to the free hydroxyl groups of DDMP decreases their reducing abilities. In particular, the hydroxyl group at the olefin position exhibited a remarkable impact on the antioxidant activity of DDMP, indicating that the unstable enol structure in the DDMP moiety is the key factor for its antioxidant activity.
Topics & Concepts
RadicalChemistryAntioxidantPyranMedicinal chemistryOrganic chemistryFree Radicals and AntioxidantsSynthesis of Organic CompoundsPhytochemicals and Antioxidant Activities