Electrochemical Oxidative C–C Bond Cleavage of Ketones for C–N Bond Formation: A Route to Amides
Yonghui He, Liang Zeng, Ming Li, Lijun Gu, Shengyong Zhang, Ganpeng Li
Abstract
Herein, we report an efficient electrochemical activation of the C-C bond of aryl ketones for the preparation of amides under catalyst- and external-oxidant-free conditions using aliphatic amines as the N source. Under environmentally benign electrolysis conditions, a series of amides were synthesized in good yield. Our control experiments revealed that electricity plays an important role in this transformation.
Topics & Concepts
ChemistryElectrochemistryElectrolysisBond cleavageYield (engineering)CatalysisArylOxidative phosphorylationOrganic chemistryCombinatorial chemistryMedicinal chemistryElectrodeAlkylMaterials scienceBiochemistryPhysical chemistryMetallurgyElectrolyteRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods