Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b]pyridazine derivatives as potent PI3K/mTOR dual inhibitors
Chuchu Li, Yuqiao Han, Zhengyang Wang, Yanan Yu, Chen Wang, Ziwei Ren, Yanzhi Guo, Tong Zhu, XuWen Li, Suzhen Dong, Ming‐Liang Ma
Topics & Concepts
PI3K/AKT/mTOR pathwayChemistryIn vivoPyrazinePyridazineBioavailabilityIn vitroPharmacologyProtein kinase BSignal transductionIC50KinaseBiochemistryStereochemistryBiologyBiotechnologyPI3K/AKT/mTOR signaling in cancerQuinazolinone synthesis and applicationsCancer Mechanisms and Therapy