NOD2/c-Jun NH <sub>2</sub> -Terminal Kinase Triggers Mycoplasma ovipneumoniae-Induced Macrophage Autophagy
Haixia Luo, Xixi Wu, Zhaokun Xu, Xiujing Hao, Yongyu Wang, Min Li
Abstract
M. ovipneumoniae , which lacks a cell wall, causes infectious pleuropneumonia in goats and sheep. In the present study, we focused on the interaction between NOD and M. ovipneumoniae , as well as its association with autophagy. We showed for the first time that NOD2 was activated by M. ovipneumoniae even when peptidoglycans were not present. We also observed that both NOD2 and JNK pathway activation promoted M. ovipneumoniae -induced autophagy.
Topics & Concepts
BiologyAutophagyNOD2NodCell biologyMacrophageMolecular biologyInnate immune systemMicrobiologyImmunologyImmune systemGeneBiochemistryApoptosisIn vitroMicrobial infections and disease researchAutophagy in Disease and TherapyVibrio bacteria research studies