A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst
Noboru Hayama, Yusuke Kobayashi, Eriko Sekimoto, Anna Miyazaki, Kiyofumi Inamoto, Tetsutaro Kimachi, Yoshiji Takemoto
Abstract
An asymmetric thia-Michael addition of arylthiols to α,β-unsaturated carboxylic acids using a thiourea catalyst that bears arylboronic acid and tertiary amine moieties is reported.
Topics & Concepts
ThioureaMichael reactionChirality (physics)CatalysisChemistryCarboxylic acidOrganic chemistrySolventChiral symmetryPhysicsNambu–Jona-Lasinio modelQuarkQuantum mechanicsAsymmetric Synthesis and CatalysisChemical Synthesis and ReactionsSulfur-Based Synthesis Techniques