Biocompatibility of biphasic α,β-tricalcium phosphate ceramics in vitro
Т. В. Сафронова, И. И. Селезнева, С. А. Тихонова, А.С. Киселев, Galina A. Davydova, Т. Б. Шаталова, D. S. Larionov, Julietta V. Rau
Abstract
The biocompatibility of biphasic α,β-tricalcium phosphate ceramics, obtained by annealing a compact preform based on β-tricalcium phosphate powder, was studied in vitro. It was found that within 10–30 days the adhesion of primary dental pulp stem cells located on the surface of biphasic α,β-tricalcium phosphate ceramics is suppressed. Decrease of the cell number on the surface of biphasic α,β-tricalcium phosphate ceramics, most likely, can be associated with both the pH level (acidic) as a result of hydrolysis of the more soluble phase of α-tricalcium phosphate and with the nature of surface that changes as a result of the formation and growth of hydroxyapatite crystals.