Biorelevant Weakly Coordinating Directing Group Assisted C–H Alkenylation with Cyclopropanols via Sequential C–H/C–C Activation
Tripti Paul, Shubhajit Basak, Maniya V. Nanjegowda, Tharmalingam Punniyamurthy
Abstract
A weakly coordinating biorelevant intrinsic directing group (DG) assisted site-selective C-H alkenylation via sequential C-H/C-C bond activation has been accomplished under Ru(II)-catalysis using readily accessible cyclopropyl alcohol as an alkenyl surrogate. Utilization of an intrinsic DG, exclusive regioselectivity, functional group diversity, late-stage natural product and drug mutations are the important practical features.
Topics & Concepts
ChemistryRegioselectivityCatalysisAlcoholStereochemistryNatural productMedicinal chemistryCombinatorial chemistryLeaving groupGroup (periodic table)BiochemistryOrganic chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms