Macrocyclic Transmembrane Anion Transporters via a One-Pot Condensation Reaction
Parichita Saha, Nandita Madhavan
Abstract
Synthetic chloride transporters are potential therapeutic agents for cystic fibrosis and cancer. Reported herein are macrocyclic transmembrane chloride transporters prepared by a one-pot condensation reaction. The most efficient macrocycle possesses a fine balance of hydrophobicity for membrane permeation and hydrophilicity for ion recognition. The macrocycle transports chloride ions by forming channels in the membrane. Hydrogen bonds and anion-π interactions assist chloride transport.
Topics & Concepts
ChemistryTransmembrane proteinChloridePermeationMembraneCondensationIonCombinatorial chemistryChloride channelTransporterHydrogen bondIon transporterOrganic chemistryMoleculeBiochemistryReceptorGeneThermodynamicsPhysicsMolecular Sensors and Ion DetectionSupramolecular Chemistry and ComplexesDNA and Nucleic Acid Chemistry