Discovering the Solid-State Secrets of Lorlatinib by NMR Crystallography: To Hydrogen Bond or not to Hydrogen Bond
Zainab Rehman, W. Trent Franks, Bao N. Nguyen, Heather Frericks Schmidt, Garry Scrivens, Steven P. Brown
Abstract
H Larmor frequency of 1 GHz as compared to 500 or 600 MHz is demonstrated.
Topics & Concepts
CrystallographyChemistryHydrogen bondMoleculeChemical shiftMagic angle spinningIntermolecular forceSolid-state nuclear magnetic resonanceNMR spectra databaseProton NMRSingle crystalCrystal structureNuclear magnetic resonance spectroscopySpectral lineNuclear magnetic resonanceStereochemistryPhysical chemistryOrganic chemistryPhysicsAstronomyAdvanced NMR Techniques and ApplicationsSolid-state spectroscopy and crystallographyMuon and positron interactions and applications