Human lung CD8+ tissue-resident memory T cell-derived interferon-γ orchestrates subset-specific antiviral programming in airway epithelial cells
Cameron L R Mattingly, Ariana R. Jimenez, M Elliott Williams, Kirsten Kost, Laurel A. Lawrence, Thien Duy Chen, Sarah Michalets, Jenna L Lobby, Yixel Soto-Vázquez, Kathryn M. Moore, Sakeenah L. Hicks, Shamika Danzy, Jennifer L. Elliott, Christopher D. Scharer, Alison Swaims-Kohlmeier, Anice C. Lowen, Aneesh K. Mehta, Jacob E. Kohlmeier
Abstract
Trm cell activation. In air-liquid interface cultures modeling influenza infection of the lung, rapid IFNγ signaling was necessary and sufficient to activate antiviral pathways in stratified epithelium and protect against infection. Thus, lung Trm cells coordinate early mucosal defense through rapid IFNγ-driven epithelial programming to restrict respiratory virus propagation in humans.
Topics & Concepts
BiologyLungEffectorImmunologyInnate immune systemImmune systemTissue tropismRespiratory epitheliumEpitheliumTropismCell biologyVirusPhenotypeAntigenAntigen presentationViral entryVirologyT cellRespiratory systemSignal transductionCellAcquired immune systemHuman cytomegalovirusViral replicationCell cultureT-cell and B-cell ImmunologyImmunodeficiency and Autoimmune DisordersCytomegalovirus and herpesvirus research