Mutual promotion of oxidative stress amplification and calcium overload by degradable spatially selective self-cascade catalyst for synergistic tumor therapy
Xiang Wang, Chunlin Li, Hansong Jin, Xingyan Wang, Cheng Ding, Dongmiao Cao, Linjing Zhao, Guoying Deng, Jie Lü, Zhiping Wan, Xijian Liu
Topics & Concepts
Oxidative stressGlutathioneChemistryReactive oxygen speciesCalciumIntracellularTumor promotionTumor microenvironmentOxidative phosphorylationApoptosisCalcium in biologyTumor hypoxiaMitochondrionHypoxia (environmental)BiophysicsCancer researchCell biologyBiochemistryOxygenTumor cellsBiologyEnzymeCarcinogenesisMedicineRadiation therapyOrganic chemistryGeneInternal medicineNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisNanoparticle-Based Drug Delivery