Single-cell transcriptome identifies FCGR3B upregulated subtype of alveolar macrophages in patients with critical COVID-19
Nasna Nassir, Richa Tambi, Asma Bankapur, Saba Al Heialy, Noushad Karuvantevida, Hamda Khansaheb, Binte Zehra, Ghausia Begum, Reem Abdel Hameid, Awab Ahmed, Zulfa Deesi, Abdulmajeed Alkhajeh, K. M. Furkan Uddin, Hosneara Akter, Seyed Ali Safizadeh Shabestari, Omar Almidani, Md. Amirul Islam, Mellissa Gaudet, Richard K. Kandasamy, Tom Loney, Ahmad Abou Tayoun, Norbert Nowotny, Marc Woodbury‐Smith, Proton Rahman, Wolfgang M. Kuebler, Mahmood Yaseen Hachim, Jean-Laurent Casanova, Bakhrom K. Berdiev, Alawi Alsheikh‐Ali, Mohammed Uddin
Abstract
may identify a specific subtype of MoAM in patients with severe COVID-19 that may present a novel biomarker for screening and prognosis, as well as a potential therapeutic target.
Topics & Concepts
TranscriptomeBronchoalveolar lavageDownregulation and upregulationBiomarkerCoronavirus disease 2019 (COVID-19)PneumoniaBiologyImmunologyMedicinePathologyGeneDiseaseLungGene expressionInternal medicineGeneticsInfectious disease (medical specialty)COVID-19 Clinical Research StudiesImmune cells in cancerSingle-cell and spatial transcriptomics