hPSC-derived organoids: models of human development and disease
Tristan Frum, Jason R. Spence
Abstract
Organoids derived from human pluripotent stem cells (hPSCs) have emerged as important models for investigating human-specific aspects of development and disease. Here we discuss hPSC-derived organoids through the lens of development-highlighting how stages of human development align with the development of hPSC-derived organoids in the tissue culture dish. Using hPSC-derived lung and intestinal organoids as examples, we discuss the value and application of such systems for understanding human biology, as well as strategies for enhancing organoid complexity and maturity.
Topics & Concepts
OrganoidInduced pluripotent stem cellBiologyDevelopmental biologyComputational biologyEmbryonic stem cellCell biologyNeuroscienceGeneticsGeneRenal and related cancersPluripotent Stem Cells ResearchNeonatal Respiratory Health Research