A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation
Chaitanya A. Kulkarni, Brian D. Fink, Bettine E. Gibbs, Pratik Rajesh Chheda, Meng Wu, William I. Sivitz, Robert J. Kerns
Abstract
moiety as an inert mitochondria-targeting carrier to safely target pharmacophores and probes to mitochondria.
Topics & Concepts
MitochondrionOxidative phosphorylationChemistryMoietyLipophilicityPhosphorylationLinkerInner mitochondrial membraneConjugatePharmacophoreBiochemistryBiophysicsStereochemistryBiologyMathematical analysisOperating systemComputer scienceMathematicsMitochondrial Function and PathologyATP Synthase and ATPases ResearchMolecular Sensors and Ion Detection