The application of proteomics in the diagnosis and treatment of bronchial asthma
Peng Xu, Lingwei Wang, Dandan Chen, Mengjie Feng, Yongzhen Lu, Rongchang Chen, Chen Qiu, Jie Li
Abstract
Bronchial asthma is a common chronic inflammatory disease of the airways. Although its pathogenic mechanism remains unknown, it is influenced by both genetic and environmental factors. The emergence and application of proteomic technologies can help to facilitate analysis of the changes in transcription factors, inflammatory mediators, chemokines, cytokines, and cell apoptosis-and proliferation-related proteins in the pathological processes of asthma. Proteomic technologies can unearth prospects and theoretical bases for improved understanding of the biological mechanism of asthma and effective identification of diagnostic and therapeutic targets.