High concentrations of triglycerides are associated with diabetic kidney disease in new‐onset type <scp>2</scp> diabetes in <scp>C</scp> hina: Findings from the <scp>C</scp> hina <scp>C</scp> ardiometabolic <scp>D</scp> isease and <scp>C</scp> ancer <scp>C</scp> ohort ( <scp>4C</scp> ) <scp>S</scp> tudy
Lei Gong, Chuan Wang, Guang Ning, Weiqing Wang, Gang Chen, Qin Wan, Guijun Qin, Li Yan, Guixia Wang, Yingfen Qin, Zuojie Luo, Xulei Tang, Yanan Huo, Ruying Hu, Zhen Ye, Lixin Shi, Zhengnan Gao, Qing Su, Yiming Mu, Jiajun Zhao, Lulu Chen, Lulu Chen, Tianshu Zeng, Xuefeng Yu, Qiang Li, Feixia Shen, Yinfei Zhang, Youmin Wang, Huacong Deng, Chao Liu, Shengli Wu, Tao Yang, Yufang Bi, Jieli Lu, Mian Li, Yu Xu, Min Xu, Tiange Wang, Zhiyun Zhao, Xinguo Hou, Li Chen, Li Chen
Abstract
AIMS: The aims of this study were to evaluate the associations of metabolic abnormalities with incident diabetic kidney disease (DKD) and to explore whether dyslipidaemia, particularly high fasting triglyceride (TG), was associated with the development of DKD. METHODS: at follow-up. Multiple logistic regression analysis was conducted to explore the relationship of metabolic abnormalities at baseline and at follow-up with risks of DKD. High TG was defined by TG ≥1.70 mmol/L. Low high-density lipoprotein cholesterol (HDL-c) was defined by HDL-c <1.0 mmol/L for men or <1.3 mmol/L for women. RESULTS: Participants who developed DKD had higher levels of waist circumference and systolic blood pressure, and lower levels of HDL-c at both baseline and follow-up visits. The DKD group also had higher levels of post-load plasma glucose and TG at follow-up. Multivariate logistic regression analysis revealed that both high TG at baseline [odds ratio (OR) = 1.37, p = .012) and high TG at follow-up (OR = 1.71, p < .001) were significantly associated with increased risks of DKD. Patients with high TG levels at both baseline and follow-up had higher risk of DKD compared with constantly normal TG (OR = 1.65, p < .001) after adjustment for covariates. CONCLUSIONS: In a large population of patients with new-onset type 2 diabetes, a high TG level was an independent risk factor for the development of DKD. Tight TG control might delay the occurrence of DKD.