Enantioselective Synthesis of Tetrahydroquinolines <i>via</i><scp>One‐Pot</scp> Cascade Biomimetic Reduction<sup>†</sup>
Zi‐Biao Zhao, Xiang Li, Mu‐Wang Chen, Bo Wu, Yong‐Gui Zhou
Abstract
Summary of main observation and conclusion A novel and efficient protocol for the synthesis of chiral tetrahydroquinoline derivatives with excellent enantioselectivities and high yields has been developed through one‐pot cascade biomimetic reduction. The detailed reaction pathway includes the acid‐catalyzed and ruthenium‐catalyzed formation of aromatic quinoline intermediates and biomimetic asymmetric reduction.
Topics & Concepts
ChemistryEnantioselective synthesisCascadeRutheniumQuinolineCombinatorial chemistryCatalysisBiomimetic synthesisReduction (mathematics)Organic chemistryChromatographyGeometryMathematicsAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisAsymmetric Synthesis and Catalysis