Mesoporous polydopamine nanoparticles for sustained release of rapamycin and reactive oxygen species scavenging to synergistically accelerate neurogenesis after spinal cord injury
Haifei Shi, Lulu Jin, Jinyi Li, Kejiong Liang, Xigong Li, Ziqiang Ye, Xinyue Zhu, Joaquím M. Oliveira, Rui L. Reis, Zhengwei Mao, Mengjie Wu
Abstract
experiments proved that mPDA@Rapa nanoparticles had a good ROS scavenging ability towards hydrogen peroxide and hydroxyl radicals. Furthermore, mPDA@Rapa also showed a good therapeutic effect in SCI model rats, which was evidenced by a smaller injury cavity, more coordinated hind limb movements, and a higher degree of neurogenesis and tissue regeneration. Our work provides a combined strategy to inhibit ROS overproduction and eliminate excess ROS, with potential applications not only in SCI, but also in other ROS-induced inflammations.
Topics & Concepts
Reactive oxygen speciesPI3K/AKT/mTOR pathwayNanocarriersOxidative stressChemistryMesoporous materialCell biologyNeurogenesisPharmacologyNanoparticleBiophysicsMaterials scienceBiochemistryBiologyApoptosisNanotechnologyCatalysisSpinal Cord Injury ResearchMXene and MAX Phase MaterialsDielectric materials and actuators