Dual-sensitive fluorescent nanoprobes for detection of matrix metalloproteinases and low pH in a 3D tumor microenvironment
Simran Kaur Rainu, Sowmya Parameswaran, Subramanian Krishnakumar, Neetu Singh
Abstract
systems revealed that low pH and high MMP-9 levels could be successfully visualised using these dual-sensitive nanoprobes. Therefore, these nanoprobes would find potential applications as a non-invasive imaging tool for visualising tumor margins in real-time.
Topics & Concepts
Matrix metalloproteinaseTumor microenvironmentFluorescenceDownregulation and upregulationMaterials scienceMatrix (chemical analysis)BiophysicsNanotechnologyDual (grammatical number)ChemistryTumor cellsCancer researchBiochemistryBiologyOpticsComposite materialArtPhysicsLiteratureGeneNanoplatforms for cancer theranosticsAdvanced biosensing and bioanalysis techniquesAdvanced Nanomaterials in Catalysis