Tetrahedral Framework Nucleic Acids Connected with MicroRNA-126 Mimics for Applications in Vascular Inflammation, Remodeling, and Homeostasis
Yichen Ge, Qingxuan Wang, Xin Qin, Songhang Li, Zhiqiang Liu, Yunfeng Lin, Xiaobing Li, Xiaoxiao Cai
Abstract
. The mechanisms underlying these phenomena were demonstrated to be related to the downregulation of caspase3 and negative regulators of VEGF (SPRED1 and PIK3R2). Moreover, tFNAs-MMs promoted the migration and proliferation of HUVECs. Briefly, the strategy of sticky-end-modified tFNAs connecting miRNA mimics is available for miRNA gain of function, while tFNAs-MMs might be a promising agent for repairing early stage vascular damage and maintaining vascular homeostasis.
Topics & Concepts
AngiogenesisCell biologyHomeostasismicroRNAUmbilical veinBiologyDownregulation and upregulationInflammationApoptosisEndothelial stem cellCell migrationEndotheliumCellImmunologyIn vitroCancer researchBiochemistryGeneGeneticsMicroRNA in disease regulationRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques