Absence of mucosal-associated invariant T cells in a person with a homozygous point mutation in <i>MR1</i>
Lauren J. Howson, Wael Awad, Anouk von Borstel, Hui Jing Lim, Hamish E. G. McWilliam, Maria L. Sandoval-Romero, Shamik Majumdar, Abdul Rezzak Hamzeh, T. Daniel Andrews, David H. McDermott, Philip M. Murphy, Jérôme Le Nours, Jeffrey Y. W. Mak, Ligong Liu, David P. Fairlie, James McCluskey, Jóse A. Villadangos, Matthew Cook, Stephen T. Turner, Martin S. Davey, Samar Ojaimi, Jamie Rossjohn
Abstract
could bind and be up-regulated by a MAIT cell inhibitory ligand, the patient lacked circulating MAIT cells. This shows the importance of the stimulatory ligand for MAIT cell selection in humans. The patient had an expanded γδ T cell population, indicating a compensatory interplay between these unconventional T cell subsets.
Topics & Concepts
BiologyMutationPoint mutationPopulationCellT-cell receptorT cellLigand (biochemistry)Cell biologyPhenotypeImmunologyGeneticsReceptorImmune systemGeneMedicineEnvironmental healthImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses